Daniel Rader High School of Telecommunication Arts and Technology

Daniel J Rader

Seymour Gray Professor of Molecular Medicine

Managing director, Preventive Cardiovascular Medicine and Lipid Clinic, University of Pennsylvania Health Organization

Associate Director, Establish for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine

Manager, Cardiovascular Metabolism Unit, Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania School of Medicine

Program Manager, General Clinical Research Center, Academy of Pennsylvania Medical Center

Span Funding Program Committee, Perelman School of Medicine at the University of Pennsylvania

Commission on Appointments and Promotions, Section of Medicine, Perelman School of Medicine at the University of Pennsylvania

Scientific Director, Clinical and Translational Inquiry, Cardivascular Plant, Perelman Schoolhouse of Medicine at the Academy of Pennsylvania

Chief, Partitioning of Translational Medicine and Human Genetics, Department of Medicine, Perelman School of Medicine at the Academy of Pennsylvania

Director, PennMedicine BioBank, Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine

Chair, Department of Genetics, Perelman Schoolhouse of Medicine at The Academy of Pennsylvania

Department: Medicine

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Education:
B.A.
Lehigh University, 1981.
Thou.D.
Medical College of Pennsylvania, 1984.

Post-Graduate Training
Internship, Internal Medicine, Yale-New Oasis Hospital, New Haven, CT, 1984-1985.
Residency, Internal Medicine, Yale-New Haven Hospital, New Oasis, CT, 1985-1987.
Chief Resident, Internal Medicine, Yale School of Medicine, New Haven, CT, 1987-1988.
Medical Staff Fellow, Molecular Illness Branch, National Heart, Lung, and Blood Constitute, Bethesda, Maryland, 1988-1991.

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Inquiry Interests
The Rader laboratory is focused on ii major themes: 1) novel pathways regulating lipid and lipoprotein metabolism and atherosclerosis inspired by unbiased studies of homo genetics; 2) factors regulating the structure and function of loftier density lipoproteins and the process of opposite cholesterol transport and their relationship to atherosclerosis. A variety of basic prison cell and molecular laboratory techniques, mouse models, and translational research approaches are used in addressing these questions.

Some examples of ongoing projects are:
i) The roles of sortilin (factor SORT1) and tribbles-1 (gene TRIB1) in lipoprotein metabolism and atherosclerosis. Variants at the SORT1 locus are among the nigh strongly associated with LDL cholesterol and (coronary artery disease) in the human genome, and variants at the TRIB1 locus are significantly associated with all major plasma lipid traits and CAD. A diverseness of tissue-specific deleted mouse models, cistron targeting in iPS cells with differentiation to hepatocytes, and cell biologic and biochemical approaches are being employed.

two) Functional genomics and mechanistic studies of a number of additional genes at loci significantly associated with lipid and metabolic traits, CAD, or other cardiovascular traits. Most of these genes harbor rare coding variants associated with these traits. In improver to elucidating primal mechanisms by which the poly peptide influences relevant biology, the influence of specific mutations on poly peptide construction and function are being explored.

three) Molecular regulation of HDLmetabolism and contrary cholesterol transport using cells, mice, and humans

4) Deep phenotyping of humans with low-frequency and rare variants in genes influencing lipid and cardiovascular traits, including the generation of iPS cells and differentiation to a diversity of relevant cell types

Research Lab:
11th floor, Smilow Center for Translational Enquiry

Clinical Research:
9th flooring Maloney Building, Hospital of The University of Pennsylvania

Research Interests
The Rader laboratory is focused on 2 major themes: 1) novel pathways regulating lipid and lipoprotein metabolism and atherosclerosis inspired by unbiased studies of human genetics; 2) factors regulating the structure and function of high density lipoproteins and the procedure of opposite cholesterol transport and their relationship to atherosclerosis. A variety of bones cell and molecular laboratory techniques, mouse models, and translational research approaches are used in addressing these questions.

Some examples of ongoing projects are:
ane) The roles of sortilin (gene SORT1) and tribbles-1 (cistron TRIB1) in lipoprotein metabolism and atherosclerosis. Variants at the SORT1 locus are among the about strongly associated with LDL cholesterol and (coronary avenue disease) in the human genome, and variants at the TRIB1 locus are significantly associated with all major plasma lipid traits and CAD. A variety of tissue-specific deleted mouse models, gene targeting in iPS cells with differentiation to hepatocytes, and cell biologic and biochemical approaches are being employed.

2) Functional genomics and mechanistic studies of a number of boosted genes at loci significantly associated with lipid and metabolic traits, CAD, or other cardiovascular traits. Most of these genes harbor rare coding variants associated with these traits. In addition to elucidating fundamental mechanisms by which the poly peptide influences relevant biology, the influence of specific mutations on protein structure and function are being explored.

3) Molecular regulation of HDLmetabolism and reverse cholesterol transport using cells, mice, and humans

4) Deep phenotyping of humans with depression-frequency and rare variants in genes influencing lipid and cardiovascular traits, including the generation of iPS cells and differentiation to a variety of relevant cell types

Administrative Assistant:
Linda Carmichael, 215-573-4176

Executive Assistant:
Cathy Warford, 215-573-7272

Grants Manager:
Michael S. Kelly, 215-573-1264

Research Lab:
11th flooring, Smilow Center for Translational Research

Clinical Inquiry:
9th flooring Maloney Edifice, Hospital of The University of Pennsylvania

Inquiry Group:

Enquiry Associate Professors:
Marina Cuchel, Medico PhD

Inquiry Assistant Professors:
Yanqing (Anna) Gong, PhD
Nicholas Hand, PhD

Adjunct Professors:
Sissel Lund-Katz, PhD
Michael C. Phillips, PhD

Senior Research Investigators:
Jeffrey Billheimer, PhD
John Millar, PhD
Athanasia (Nancy) Skoura, PhD

Inquiry Associates:
Nicholas Lyssenko, PhD
Sony Tuteja, PharmD

Mail service-doctoral Fellows:
Deepti Abbey, PhD
Ezimamaka Ajufo, Dr.
Robert Bauer, PhD
Xin Bi, PhD
Donna Conlon, PhD
Marie Guerraty, MD/PhD
Ali Javaheri, MD/PhD
Sylvia Nürnberg, PhD
Evanthia Pashos, PhD
Swapnil Shewale, PhD

Doris Duke Boyfriend:
Aeron Small

Visiting Scientists:
Jian Cui, Physician
Marjolein van den Boogert
Bijun Zhao

Graduate Students:
Devin Christopher
Sumeet Khetarpal
Hye In Kim
Wen Lin
Minal Mehta
Cecilia Vitali
Christopher Yu

Projection Managers:
Stephanie DerOhannessian, MB
Dawn Marchadier, MS

Bioinformatician:
H. Shanker Rao, MS

Biostatisticians:
Wei Zhao, MS
Jung-Jin Lee

Information Analyst:
Khalif Coaxum

Research Specialists:
Debra Cromley
Edwige Edouard
Susannah Elwyn, MS
Mayda Hernandez, MS
James McParland
Linda Morrell
Amrith Rodrigues, MS
Mikhaila Smith
Maosen Sun, MD/PhD
Teo Tran
Kevin Trindade
Aisha Wilson, MLAS

Clinical Research Personnel:

Project Managers:
Amanda Baer, MB MBA

Data Coordinators:
Marjorie Risman, MS

Clinical Research Coordinators:
Canita Brent
Maria Escobar
Polina Ferd
Dusanka Lalic
Karen Monono
Anna Sicilia
Tracey Sikora
Karen Terembula
Masako Ueda, Physician
Rahma Warsi

Clinical Research Assistants:
Muhamad Farhan
Jamila Hoque
Lauren Vincent
Laura Walters
Katy Wong

Selected Publications

Dron JS, Wang J, Low-Kam C, Khetarpal SA, Robinson JF, McIntyre Advertizing, Ban MR, Cao H, Rhainds D, Dubé MP, Rader DJ, Lettre G, Tardif JC, Hegele RA: Polygenic determinants in extremes of high-density lipoprotein cholesterol. J Lipid Res Sep 2017 Notes: Epub ahead of print. Zhao Westward, Rasheed A, Tikkanen Eastward, Lee JJ, Butterworth AS, Howson JMM, Assimes TL, Chowdhury R, Orho-Melander M, Damrauer S, Small A, Asma South, Imamura Yard, Yamauch T, Chambers JC, Chen P, Sapkota BR, Shah Northward, Jabeen Southward, Surendran P, Lu Y, Zhang W, Imran A, Abbas South, Majeed F, Trindade One thousand, Qamar N, Mallick NH, Yaqoob Z, Saghir T, Rizvi SNH, Memon A, Rasheed SZ, Memon FU, Mehmood Thou, Ahmed North, Qureshi IH, Tanveer-Usa-Salam, Iqbal Westward, Malik U, Mehra N, Kuo JZ, Sheu WH, Guo 10, Hsiung CA, Juang JJ, Taylor KD, Hung YJ, Lee WJ, Quertermous T, Lee IT, Hsu CC, Bottinger EP, Ralhan Southward, Teo YY, Wang TD, Alam DS, Di Angelantonio Due east, Epstein Due south, Nielsen SF, Nordestgaard BG, Tybjaerg-Hansen A, Immature R; CHD Exome+ Consortium, Benn Grand, Frikke-Schmidt R, Kamstrup PR; Ballsy-CVD Consortium; Epic-Collaborate Consortium; Michigan Biobank, Jukema JW, Sattar Northward, Smit R, Chung RH, Liang KW, Anand S, Sanghera DK, Ripatti Due south, Loos RJF, Kooner JS, Tai ES, Rotter JI, Chen YI, Frossard P, Maeda S, Kadowaki T, Reilly M, Pare G, Melander O, Salomaa 5, Rader DJ, Danesh J, Voight BF, Saleheen D. : Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary eye illness. Nat Genet Sep 2017 Notes: Epub ahead of impress. Tuteja Southward, Wang 50, Dunbar RL, Chen J, DerOhannessian Due south, Marcovina SM, Elam M, Lader E, Rader DJ: Genetic coding variants in the niacin receptor, hydroxyl-carboxylic acid receptor 2, and response to niacin therapy. Pharmacogenet Genomics. 27(8): 285-293, Aug 2017. Dunbar RL, Movva R, Bloedon LT, Duffy D, Norris RB, Navab Thousand, Fogelman AM, Rader DJ.: Oral Apolipoprotein A-I Mimetic D-4F Lowers HDL-Inflammatory Alphabetize in Loftier-Risk Patients: A First-in-Human Multiple-Dose, Randomized Controlled Trial. Clin Transl Sci Aug 2017 Notes: Epub ahead of print. Bajaj A, Damrauer SM, Anderson AH, Xie D, Budoff MJ, Get Equally, He J, Lash JP, Ojo A, Post WS, Rahman K, Reilly MP, Saleheen D, Townsend RR, Chen J, Rader DJ: Lipoprotein(a) and Chance of Myocardial Infarction and Death in Chronic Kidney Disease: Findings From the CRIC Study (Chronic Renal Insufficiency Cohort). Arterioscler Thromb Vasc Biol Aug 2017 Notes: Epub alee of print. Koekemoer AL, Codd Five, Masca NGD, Nelson CP, Musameh MD, Kaess BM, Hengstenberg C, Rader DJ, Samani NJ : Big-Calibration Assay of Determinants, Stability, and Heritability of High-Density Lipoprotein Cholesterol Efflux Capacity. Arterioscler Thromb Vasc Biol Aug 2017 Notes: Epub ahead of print. Khetarpal SA, Zeng X, Millar JS, Vitali C, Somasundara AVH, Zanoni P, Landro JA, Barucci North, Zavadoski WJ, Sunday Z, de Haard H, Toth IV, Peloso GM, Natarajan P, Cuchel M, Lund-Katz Due south, Phillips MC, Tall AR, Kathiresan S, DaSilva-Jardine P, Yates NA, Rader DJ : A human being APOC3 missense variant and monoclonal antibody advance apoC-3 clearance and lower triglyceride-rich lipoprotein levels. Nat Med Aug 2017 Notes: Epub ahead of print. Small AM, Osculation DH, Zlatsin Y, Birtwell DL, Williams H, Guerraty MA, Han Y, Anwaruddin S, Holmes JH, Chirinos JA, Wilensky RL, Giri J, Rader DJ: Text mining applied to electronic cardiovascular process reports to place patients with trileaflet aortic stenosis and coronary artery disease. J Biomed Inform 72: 77-84, Aug 2017. Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, Sun BB, Eicher JD, Johnson AD, Sheu WHH, Nielsen SF, Lin WY, Surendran P, Malarstig A, Wilk JB, Tybjærg-Hansen A, Rasmussen KL, Kamstrup PR, Deloukas P, Erdmann J, Kathiresan S, Samani NJ, Schunkert H, Watkins H; CARDIoGRAMplusC4D, Do R, Rader DJ, Johnson JA, Hazen SL, Quyyumi AA, Spertus JA, Pepine CJ, Franceschini Northward, Justice A, Reiner AP, Buyske S, Hindorff LA, Carty CL, North KE, Kooperberg C, Boerwinkle E, Young K, Graff Grand, Peters U, Absher D, Hsiung CA, Lee WJ, Taylor KD, Chen YH, Lee Information technology, Guo X, Chung RH, Hung YJ, Rotter JI, Juang JJ, Quertermous T, Wang TD, Rasheed A, Frossard P, Alam DS, Majumder AAS, Di Angelantonio E, Chowdhury R; EPIC-CVD, Chen YI, Nordestgaard BG, Assimes TL, Danesh J, Butterworth AS, Saleheen D. : Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet 49(vii): 1113-1119, Jul 2017. Dewey FE, Gusarova V, Dunbar RL, O'Dushlaine C, Schurmann C, Gottesman O, McCarthy S, Van Hout CV, Bruse Due south, Dansky HM, Leader JB, Murray MF, Ritchie Medico, Kirchner HL, Habegger Fifty, Lopez A, Penn J, Zhao A, Shao Westward, Stahl Northward, Murphy AJ, Hamon Due south, Bouzelmat A, Zhang R, Shumel B, Pordy R, Gipe D, Herman GA, Sheu WHH, Lee It, Liang KW, Guo X, Rotter JI, Chen YI, Kraus We, Shah SH, Damrauer Due south, Small A, Rader DJ, Wulff AB, Nordestgaard BG, Tybjærg-Hansen A, van den Hoek AM, Princen HMG, Ledbetter DH, Carey DJ, Overton JD, Reid JG, Sasiela WJ, Banerjee P, Shuldiner AR, Borecki IB, Teslovich TM, Yancopoulos GD, Mellis SJ, Gromada J, Baras A.: Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Affliction. Northward Engl J Med 377(three): 211-221, Jul 2017.

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Terminal updated: 08/25/2021
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Source: https://www.med.upenn.edu/apps/faculty/index.php/g5455356/p17778

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